Leukemia-associated antigens are often overexpressed in leukemia blasts and absent in normal tissue such as Wilms tumor 1 (WT-1), preferentially expressed antigen in melanoma (PRAME), melanoma family antigen (MAGE), receptor for hyaluron mediated motility (RHAMM), testis antigens like New York esophageal squamous cell carcinoma-1 cancer-testis antigen (NY3ESO), and granulocyte antigens such as PR1 (a 9 amino acid HLA-A*0201-restricted peptide derived from proteinase3). Here, PRAME is linked to leukemia.