Moreover, a diet supplemented with 1% anthocyanin extracts was able to prevent cognitive deficits in a transgenic AD mouse model (Yamakawa et al., 2016) whereas pomegranate polyphenol administration exerted anti-inflammatory effects on a transgenic AD mouse model by reducing TNF-α brain levels and microgliosis (Rojanathammanee et al., 2013). Here, TNF is linked to Alzheimer disease.