Also, as previously stated, triazinones displayed anti-GSK-3 and anti-BACE-1 activity (Prati et al., 2015) while NB-360, another BACE-1 inhibitor was able to block Aβ deposition and the accumulation of inflammatory cells in a transgenic AD mouse model (Neumann et al., 2015). The gene discussed is BACE1; the disease is Alzheimer disease.