The amount of BACE1 protein (~70 kDa) appeared to be increased among the AD cases relative the other two groups (Figure 8D), with densitometry indicating an overall difference (P = 0.0003, KWI = 16.0) between the AD (138.7 ± 15.1%), and Aged (118.2 ± 22.1%) and Mid-age (105.9 ± 16.2%) groups, and significant difference between the AD and Mid-age groups by post hoc test (Figure 8E5). The gene discussed is BACE1; the disease is Alzheimer disease.