The bands of full-length APP protein (~100 kDa) blotted with the 6E10 antibody appeared to be denser among the AD cases (Figure 7E), with an overall difference of its levels between AD (183.9 ± 13.2%), Aged (151.6 ± 27.4%) and Mid-age (88.1 ± 43.9%) groups (P = 0.0003, KWI = 16.0), elevated in the AD relative to the Mid-age groups by post hoc test (Figure 8E4). Here, APP is linked to Alzheimer disease.