Additionally, both SMMC.7721 and scrambled shRNA-transfected SMMC.7721 tumors resected from platelet releasates-treated group exhibited significantly higher proliferation (Fig. 4C and Supplemental Fig. 4) and a lower apoptosis rate (Fig. 4D) compared with tumors excised from control mice, as based on the numbers of Ki67-positive tumor cells and the ratio of the relative intensities of Bax and Bcl-2 in tumor cells. This evidence concerns the gene BCL2 and neoplasm.