Currently, lapatinib is the only tyrosine kinase inhibitor approved for treatment of HER2 positive breast cancer, while the only other approved HER2 targeted therapies are the humanised antibodies trastuzumab and pertuzumab, and the antibody-drug conjugate Ado-trastuzumab-DM1 (T-DM1)15, 35, 36. This evidence concerns the gene ERBB2 and breast carcinoma.