SMAD4 and familial pancreatic carcinoma: Interestingly, in KP4-4 cells, a SMAD4-depleted pancreatic cancer cell line, the MET phenotype was induced by miR-509-5p but not by miR-1243, suggesting that the mechanism by which the MET phenotype is induced by miR-1243 might depend on the TGF-β signaling pathway (Fig. 2c).