LH-21 treatment was not associated with a decrease in obesity-induced macrophage infiltration of the islets (Fig. 3A) and did not revert the obesity-induced decrease in M2 macrophages, as assessed by Mrc-1 and CD163 immunostaining (Supplementary Figure 3A,B). The gene discussed is CD163; the disease is obesity due to melanocortin 4 receptor deficiency.