Although serum ALT levels were not differentially changed by Wnt2b-overexpressing/silencing (Supplementary Fig. S4), suggesting that the exacerbated fibrosis effect mediated by Wnt2b silencing might not be directly associated with hepatocytes injury38, further investigation on the roles of hepatocytes on liver fibrosis is still important in the future39. The gene discussed is GPT; the disease is Hepatic fibrosis.