Importantly, hyporesponsive TLR4 mutations, such as D299G and T399I single nucleotide polymorphisms (SNPs), have shown to reduce the risk of liver fibrosis in patients with hepatitis C virus infection, promising the pro-fibrogenic role of TLR4 in a clinically relevant setting15, 16. The gene discussed is TLR4; the disease is Hepatic fibrosis.