Furthermore, given that we previously have reported that mTORC1 and 2 regulates the plasma membrane trafficking of specific amino acid transporter isoforms (SNAT 2 and LAT1)27, the finding that folate deficiency in vivo in mice specifically decreased the protein expression of these two isoforms in the trophoblast plasma membrane, suggest that that the down regulation of placental amino acid transport in folate deficient dams are a result of mTORC1 and 2 inhibition. The gene discussed is SLC7A5; the disease is hyperinsulinemic hypoglycemia, familial, 4.