Maternal folate deficiency decreased the expression/phosphorylation of the downstream targets of mTORC1 signaling such as raptor, mTOR-S-2448, S6K-T-389, 4E-BP1-T-70 in the fetal liver (Supplementary Figure 4c). Here, RPS6KB1 is linked to hyperinsulinemic hypoglycemia, familial, 4.