In order to determine PJI-associated gene expression patterns in periprosthetic tissues, we compared gene expression levels of 12 candidate molecules (TLR1, -2, -4, -6, and -10, DEFA1, LTF, IL1B, BPI, CRP, IFNG, and DEFB4A) previously reported as potential biomarkers for detection of PJI in tissues obtained from patients with TJA during revision surgery. This evidence concerns the gene BPI and juvenile polyposis syndrome.