TNF and hematologic disorder: Collectively, we observed both quantitative (reduction in numbers of ECs and MSCs) and qualitative (inflammation and TNF signaling) disruption of the BM microenvironment in Flt3-ITD mice, which likely underlie the observed extrinsic suppression of HSCs, in agreement with other studies implying that hematologic malignancies dysregulate HSC niches (Schepers et al., 2015).