The role of PTPRG in controlling hematopoietic cell survival/differentiation is further supported by an early study [3], while the most recent evidence linking PTPRG to the pathogenesis of leukemia would be in keeping with inhibition of PTPRG expression by epigenetic regulation consisting in methylation of selected promoter regions and the fact that its downregulation cooperates with RAS gene activation in childhood acute lymphoblastic leukemia (ALL) [26]. This evidence concerns the gene PTPRG and acute lymphoblastic leukemia.