MEG3 and cancer: For instance, it has been found that HOTAIR lncRNA overexpression correlates with aggressive breast [27], ovarian [28], cervical [29], endometrial [30], colorectal [31], hepatocellular [32] and gastrointestinal stromal tumors [33], whereas MEG3 lncRNA may act as a tumor suppressor in a variety of human cancers such as ovarian cancer, breast cancer, hepatocarcinoma and uterine cancer [34].