Recent experimental studies showed that exogenously added S100A8 and S100A9 proteins enhanced the proliferation of tumor cells such as breast cancer cells, colorectal and pancreatic cancer cells [17, 18]; the overexpression of intracellular S100A8 protein had a growth-promoting activity in keratinocytes [19]. The gene discussed is S100A8; the disease is familial pancreatic carcinoma.