NF1 and breast carcinoma: Additionally, somatic mutations of NF1 are also frequent in desmoplastic, cutaneous and mucosal melanoma, high-grade serous ovarian cancer, breast cancer, phaeochromocytomas and paragangliomas, glioblastoma multiforme, myeloid malignancies, neuroblastoma, and colorectal and urinary bladder transitional cell carcinoma (Table 1).