In this review, we detail the frequency of somatic NF1 mutations in many non-NF1-associated sporadic cancers including melanoma, glioblastoma, neuroblastoma, breast cancer, ovarian serous carcinoma, paraganglioma and phaeochromocytoma, lung adenocarcinoma, lung squamous cell carcinoma, bladder, colorectal and leukaemia. This evidence concerns the gene NF1 and melanoma.