At least 38 genes were significantly mutated in lung ADC and 20 genes in SqCC; however, only six genes, TP53, RB1, ARIDIA, CDKN2A, PIK3CA and NF1, were significantly mutated in both tumour types, and of these, TP53, CDKN2A and PIK3CA mutations had a significantly higher frequency in lung SqCC. This evidence concerns the gene PIK3CA and neoplasm.