Additionally, somatic mutations of NF1 are also frequent in desmoplastic, cutaneous and mucosal melanoma, high-grade serous ovarian cancer, breast cancer, phaeochromocytomas and paragangliomas, glioblastoma multiforme, myeloid malignancies, neuroblastoma, and colorectal and urinary bladder transitional cell carcinoma (Table 1). This evidence concerns the gene NF1 and pheochromocytoma.