Glioblastoma-associated NF1 somatic mutations are well described [132, 134, 135], with recurrent driver mutations being identified in NF1 and a number of other candidate genes (IDH1, TP53, CDK4, EGFR, PI3KR1, PIK3CA, PTEN, RB1 and CDNK2A) in GBM [132]. Here, PIK3CA is linked to glioblastoma.