Moreover, whilst simultaneous inactivation of Nf1 and expression of K-RasG12D in mouse haematopoietic cells results in AML that was fatal in primary mice within 4 weeks, in ovarian serous carcinomas, cooperation between mutant TP53 and NF1 results in a poor prognosis [92, 117]. This evidence concerns the gene NF1 and ovarian serous carcinoma.