NF1 and pheochromocytoma: Somatic NF1 mutations occurred in 35/161 (21.7%) of sporadic phaeochromocytomas, with the majority exhibiting LOH and low NF1 mRNA expression [121–123], whilst somatic mutations in the susceptibility genes NF1, MAX, RET, VHL, SDHA, SDHB, SDHC, SDHD, SDHAF2, KIF1Bβ and TMEM127 are present in 11–19% of sporadic cases [124–126].