EP300 and cancer: Likewise, direct binding of the KAT2B/P300/ZEB1 complex to the miR200c/141 promoter activates their transcription in cancer cells, but disruption of KAT2B and P300 interactions downregulates the promoter activity of miR-200c/141, indicating a direct functional regulation of miR200c/141 by the KAT2B/P300/ZEB1 complex in cancer cells [39].