As ASA-induced effects were blocked by modulation of SOX2 by PGF2α and FGF-1 in melanoma cells (Figures 6-7), we next investigated if PGF2α-FP receptor antagonist, AL8810 [54–55] can mimic ASA effects and if SOX-2 upregulation can abrogate its effect? The gene discussed is SOX2; the disease is melanoma.