CUL5 and neoplasm: Consistent with the involvement of CUL5 in eYFP-CRAF degradation, but in contradiction to earlier studies in tumor cell lines that implicated CUL5 in HSP90 client protein degradation (Ehrlich et al., 2009, Samant et al., 2014) independently of TCEB1/2, we found that siRNA knockdown of the CUL5 partner scaffold proteins TCEB2 and, to a lesser degree, TCEB1 also elicited substantial stabilization of eYFP-CRAF fluorescence.