The mechanism by which KLK7 inhibits cell proliferation is not clear but may be due to cell cycle arrest or processing of repressive factors (cytokines) such as IL‐1beta, a known substrate of KLK7 (Nylander‐Lundqvist and Egelrud, 1997) that has been shown to inhibit melanoma growth (Neville et al., 1990). This evidence concerns the gene KLK7 and melanoma.