We have previously reported that the local expression of inducible nitic oxide synthase (iNOS) as well as tumor necrosis factor (TNFα) and vascular endothelial growth factor (VEGF) in inflamed border zone of infarcted myocardium is related to the depression of cardiomyocytes contractility leading to progressive development of heart failure [40–41]. This evidence concerns the gene TNF and heart failure.