EGFR and cancer: For example, Ciardiello et al. evaluated the anti-angiogenic and antitumor activity of gefitinib (ZD1839; Iressa®), a small molecule known as an EGFR tyrosine kinase inhibitor (TKI) in human colon (GEO, SW480, and CaCo2), breast (ZR-75-1 and MCF-7 ADR), ovarian (OVCAR-3), and gastric (KATO III and N87) cancer cells, that co-expresses TGF-α and EGFR (pro-angiogenic factor) [81].