Th2 cells and Th2-derived cytokines also contribute to the local production of IgE by B cells, airway muscle contraction, and increased vascular permeability favouring inflammation and exacerbated mucus production by goblet cells, all of which leads to bronchial hyperresponsiveness and obstruction, characteristic of the late severe phases of allergic asthma. Here, IGHE is linked to allergic asthma.