Once IgE is released into the circulation, it binds through its Cε3 domain to high affinity IgE receptor (FcεRI) and CD23 located on the surface of effector cells, such as mast cells (MC) and basophils and other relevant cells in the pathophysiology of asthma, such as DC, monocytes, and smooth muscle cells (SMC). Here, IGHE is linked to asthma.