Considering the elicited physiological actions of brown seaweeds and their overlap with the reported bioactivity of SIRT6, the aim of this work was to screen brown seaweed species for novel SIRT6 modulators as potential candidates that can be used in the prevention of age-associated diseases and metabolic syndrome associated disorders, including cancer, obesity, and insulin-resistant diabetes. The gene discussed is SIRT6; the disease is cancer.