To determine whether the specific uptake and accumulation of NIR dye in liver cancer cells is mediated by HIF1α/OATP, Hep3B cells were pre-incubated with HIF1α stabilizers dimethyloxaloylglycine (DMOG) (1 mM, Millipore, Billerica, MA, USA) for 24 h, or with OATP inhibitor bromosulfophthalein (BSP) (250 μM, Sigma-Aldrich, St. This evidence concerns the gene HIF1A and liver cancer.