The activation of NF-κB can be triggered by various stimuli including tumor-necrosis factor (TNF), interleukin 1 (IL-1), interleukin 6 (IL-6), endotoxins, carcinogens, tumor promoters, microbial pathogens, free radicals, lipopolysaccharide (LPS), and radiation (UV-light, X-rays, γ-rays) [3]. Here, TNF is linked to neoplasm.