DET and IDET, sesquiterpene lactone compounds, have been shown to induce apoptosis in various cancer cells through multiple mechanisms, including mitochondrial dysfunction, reactive oxygen species (ROS) Induction, Bcl-2 family protein modulation, mitotic arrest induction, inhibition of nuclear factor kappa B (NF-κB), and signal transducers and activators of transcription 3 (STAT3) activation [22,24,34,35,36,37,38,39]. This evidence concerns the gene STAT3 and cancer.