In SiHa cells, DET induced G2/M phase arrest by down-regulating cyclin B1 and cdc2 while up-regulating p21 (CDK inhibitor) and p53, a tumor suppresser gene which regulates G2/M phase arrest by inducing p21 and lowering the intracellular level of cyclin B1 [34]. The gene discussed is CCNB1; the disease is neoplasm.