Based on previous studies, it is evident that pressure overload or angiotensin II-induced cardiac hypertrophy, was inhibited through AMPK activation by adiponectin treatment in myocytes [56,69]; and, in animal models, adiponectin has been shown to be protective for systolic and diastolic dysfunction of myocardial infarction [80,81]. This evidence concerns the gene ADIPOQ and cardiac hypertrophy.