As patients with nonalcoholic steatohepatitis also have dysregulation of postprandial glucose and lipid homeostasis, we hypothesized that serum adiponectin levels in patients with nonalcoholic steatohepatitis would respond suboptimally to a mixed meal compared with the response in obese controls [101]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.