Expression effects were tested using 600 samples from the Type 1 Diabetes Genetics Consortium (T1DGC) comprising four cell types (a) EBV (Epstein-Barr virus) resting cells (b) PMA (Phorbol 12-myristate 13-acetate) stimulated EBV cells (c) cluster of differentiation (CD)4+ T-cells, and (d) CD8+ T-cells. The gene discussed is CD8A; the disease is type 1 diabetes mellitus.