SLC5A2 and Glycosuria: More recently, a case report describes the increase in glomerular filtration rate and administration of exogenous insulin as the possible mechanisms in enhancing the effects of SGLT2 inhibitors on the kidneys in promoting glucosuria.17 Canagliflozin is primarily metabolized by uridine diphosphate glycosyltransferase (UGT) enzymes.12 UGT polymorphisms, which are well described in the literature, could be implicated in the prolonged drug effect we observed.18