Consistent with these data, researchers have observed a decrease in expression of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and neutrophil infiltration subsequent to cerebral ischemia (the third day) through inhibiting expression of intercellular adhesion molecule (ICAM-1) secondary to AMPK activation [63]. Here, PRKAA1 is linked to Cerebral ischemia.