SIRT2 and Lewy body dementia: SIRT2 activity was upregulated in PD (19%; p < 0.01), PDD (17%; p < 0.05), DLB (21%; p < 0.001), and AD (18%; p < 0.01) compared to controls whereas no significant difference was seen among the disease groups (F = 5.593; p < 0.001) (Figure 10).