Compared to the disease-causing mutations in ATP1A1 and ATP1A2, RDP is in that respect more similar to FHM2 where many of the mutations may be associated with loss-of-function, while few hotspot positions give the phenotypes in AHC and CAPOS, as also seen for hypertension-causing ATP1A1 mutations. Here, ATP1A2 is linked to alternating hemiplegia of childhood.