In conclusion, the data presented here show that LBP further decreased LPS-induced reduction of FKN and LPS-induced lung injury and these effects can be prevented by transfection with LBP shRNA plasmid or using LBP inhibitory peptide and inhibition of the activation of p38 MAPK and NF-κB signaling transduction pathways, suggesting that LBP downregulates FKN expression through the activation of p38 MAPK and NF-κB in the progression of ARDS. This evidence concerns the gene LBP and acute respiratory distress syndrome.