The Ras-associated domain family protein 1 C could induce the phosphorylation of the cancer cell ERKl/2 and thus activate the MEK-ERKl/2 signaling pathway and upregulate the expression of PIWIL1, resulting in the unlimited self-renewal of the tumor stem cells, thereby promoting the genesis and development of a tumor. The gene discussed is PIWIL1; the disease is neoplasm.