To further dissect the epigenetic deregulation in primary lung cancer, we analyzed the expression levels of HDAC1, HDAC2, HDAC5, HDAC6, DNMT1, DNMT3A, DNMT3B and DNMT3L in 49 SCCa, 41 AdCa, 15 not malignant lung disease samples (LD) and 6 normal lung tissues (NL) (Fig. 6C). This evidence concerns the gene HDAC5 and autosomal dominant cerebellar ataxia.