Worms’ eggs in the liver of mice infected by C. sinensis were all detected in both strain mice on 28 day post-infection (the infection rates of C3H/HeN and C3H/HeJ were both 100%), suggesting that the C. sinensis were successful to develop mature in this strain mouse and the levels of TLR4 were highly increased on days of 28 post-infection in C. sinensis-infected C3H mice, compared with health normal mice11. Here, TLR4 is linked to infection.