The role of mTOR in response to CpG has been well studied in human B-lymphocytes19–21 and while little is known about the role of mTOR in MMP-7 regulation, some connection can be implied from studies done in patients with lymphangioleiomyomatosis (LAM) in which MMP-7 has been found upregulated22. This evidence concerns the gene MMP7 and lymphangioleiomyomatosis.