We speculate that in the presence of the biallelic MUTYH mutation (as is the case for autosomal recessive form of adenomatous polyposis (Al-Tassan et al. 2002, Sampson et al. 2003, Sieber et al. 2003, Vogt et al. 2009)), one might, for most of patients, never have time to observe the onset of SI-NETs, since other aggressive pathologies (such as colorectal cancer) might lead to the death of the patient. This evidence concerns the gene MUTYH and colorectal cancer.