Interestingly, deficient excision of the mutagenic base 8-oxoguanine causes mutations in codon 12 of k-ras gene in mice (Xie et al. 2004) and codon 12 mutations in human K-RAS have also been described as a somatic tumor-specific change in SI-NETs (Banck et al. 2013). Here, KRAS is linked to neoplasm.