Recent Clinical Trials by Gilead Sciences are evaluating MMP activity in different solid tumors, including non-small cell lung carcinoma (NSCLC), pancreatic adenocarcinoma, colorectal cancer (CRC) and breast cancer, and their effect in the tumor microenvironment by using an anti-MMP-9 therapeutic antibody [18]. Here, MMP9 is linked to non-small cell lung carcinoma.