Combination therapy with MEK inhibitor trametinib and EGFR/HER2 dual inhibitor lapatinib has shown a synergistic effect and circumvented the resistance of MEK1‐mutated gastric cancer cells (Mizukami et al., 2015) and HER2‐positive breast cancer cells (Karakashev and Reginato, 2015) to MEK inhibitors. The gene discussed is MAP2K1; the disease is breast carcinoma.