As shown in Fig. 1C, AZD6244 induced Akt Ser473 phosphorylation only in HER2‐positive SkBr3 and BT474 but not in HER2‐negative MDA‐MB‐468, MDA‐MB‐231, and MCF‐7 breast cancer cell lines. The gene discussed is ERBB2; the disease is breast cancer.