Variables that were entered into the model prior to elimination were: Main diagnosis, age, gender, weight, presence of diabetes, presence of hypertension, presence of hyperlipidaemia, familiar history of coronary heart disease (CHD), current or prior smoking, presence of COPD, site of antiplatelet loading therapy, switching of P2Y12-inhibitor during hospital stay, presence of atrial fibrillation, active bleeding at admission, history of stroke or TIA, history of intracranial haemorrhage, planned surgery and peri-interventional anticoagulation and antiplatelet treatment regimen. The gene discussed is P2RY12; the disease is intracranial hemorrhage.