Focusing on potential paracrine PDAC-fat interactions, we selected extracellular soluble molecules that included certain proteins associated with tumor growth, survival, and metastasis (i.e., MMP8, ZA2G, TSP1, FINC, TIMP1, IL-6 and MSLN), as well as a few that were reported in the context of cellular adhesion and chemotaxis (i.e., MSLN, ZA2G, TSP1 and FINC). This evidence concerns the gene MSLN and neoplasm.