However, concentrations of both CTRP3 and CTRP5 were significantly decreased in T2DM patients compared to control (p<0.001) and both CTRP3 and CTRP5 concentrations were lower in the PDR group compared to NPDR (p<0.05, Table 1, Table A in S1 File). This evidence concerns the gene C1QTNF3 and type 2 diabetes mellitus.