NTRK1 and Alzheimer disease: Axonal degeneration and cytoskeleton disruption, which are both early features of AD and other neurodegenerative dementias [141], are associated with an imbalanced distribution and dysregulation in NGF/TrkA signaling [142], due to the loss of microtubule-binding capacity and/or accumulation of tau into the somato-dendritic compartment.