The data obtained indicate that the activation of the NGF pathway reduces APPpT668 levels by inhibiting the p54 kDa isoform of the ser/thr c-Jun N-terminal kinase (JNK), a well-known APP kinase in AD [44], through the activation of the TrkA-Sh2 containing sequence C (ShcC) signaling pathway. This evidence concerns the gene APP and Alzheimer disease.