MAPT and Alzheimer disease: This NH2-derived truncated form of tau-mapping between 26 and 250 amino acids of the longest human tau isoform (htau40) has been also detected in animal AD models characterized by an impaired NGF signaling [143] and in human AD synaptosomes in tight correlation with the synaptic changes, Aβ deposition and pathological tau alterations (phoshorylation/aggregation/misfolding) [144,145].