MAPT and early-onset autosomal dominant Alzheimer disease: A more integrative model of AD-like neurodegeneration has been also proposed in view of the fact that tau pathology without amyloidosis is a major constituent of suspected non-Alzheimer disease pathophysiology (SNAP) and subcortical tau might be the initial pathological event, with amyloid pathology developing independently of it, and possibly accentuating, tauopathy [114,115].