Thus, in this study, using mouse insulinoma (MIN6) cells, we elucidated the mechanism downregulated by astaxanthin on the palmitate-induced enhancement of either MCP-1 mRNA expression and protein secretion or alternatively production of spliced VEGF120 lacking a heparin-binding domain [20], which are key factors of induction of chronic inflammation. This evidence concerns the gene CCL2 and pancreatic insulinoma.