In vitro, this adipokine is able to activate the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) signaling pathway and therefore enhance proliferation and inhibit apoptosis of the human HCT116 colon cancer cells [26]. The gene discussed is AKT1; the disease is malignant colon neoplasm.