In addition, the authors showed significant higher mRNA expression levels of pro-inflammatory mediators (IL-1β, COX-2, and IL-8) in S. bovis-infected tissues compared to uninfected tissues, but also higher in tumorous tissues compared to the non-tumorous one, highlighting a possible role of S. bovis in inflammation-induced CRC [160]. Here, PTGS2 is linked to colorectal carcinoma.