NFKB1 and colonic neoplasm: This pathogen is also able to invade epithelial cells via its virulence factor FadA by modulating the E-cadherin signaling pathway, leading to the activation of several transcription factors such as T-cell factor (TCF), β-catenin, NF-κB, c-myc and cyclin D1 and subsequently enhanced proliferation of colon cancer cells [153].