In this study, we provide several lines of evidence showing a novel role of Cep70 in modulating sensitivity to paclitaxel of cancer cells: Cep70 expression level is related to paclitaxel sensitivity in breast cancer cell lines; Cep70 overexpression increases the paclitaxel sensitivity of breast cancer cells while knockdown of Cep70 shows the opposite effect. Here, CEP70 is linked to breast carcinoma.