EPHA1 and glioblastoma: The EPHA2 receptor is also known to interact with integrin α3 (a known substrate of the E1B-55k/E4orf6 E3 ubiquitin ligase complex) in U251MG glioblastoma cells, and contributes to the crosstalk between Eph and integrin signalling pathways at membrane protrusions [10, 47].