We determined that proteasome activity is required for ALCAM and EPHA2 reduction (Fig. 4a), and the effects of adenovirus infection on ALCAM and EPHA2 levels (Fig. 4b, c) support the contention that at least the E1B-55k/E4orf6 complex targets ALCAM and EPHA2 for ubiquitination and subsequent proteasome-mediated degradation. The gene discussed is EPHA2; the disease is adenoviridae infectious disease.