PTTG2 and cancer: Because the parent genes PTTG1 and PTTG2 were previously confirmed to be oncogenes in various cancer types 11, 15, 16, 17 and PTTG3P shares high similarity with these genes (Fig. S1), we suggested that PTTG3P plays a role in modulating PTTG1 or PTTG2 that is similar to previously reported mechanisms 18, 19.