Consistent with our previous publication 28, diabetes mellitus (DM) induced by high fat and sugar diet combined with a small dose of STZ in male ApoE−/−/LDLr−/− mice could resemble human diabetes mellitus and STAMP2 overexpression decreased risk factor of insulin resistance in diabetic ApoE−/−LDLR−/− mice (Fig. S1, Table S1). Here, STEAP4 is linked to Insulin resistance.