On the other hand, in hsa‐let‐7 g‐overexpressing cell lines, only the EGR1 and SMOX genes showed changes in their expression similar to those in NTD cases; the expression of 11 other genes changed differently upon hsa‐let‐7 g overexpression from that in NTD cases. The gene discussed is EGR1; the disease is neural tube defect.